作者
Anurag Verma, Jessica Minnier, Emily S Wan, Jennifer E Huffman, Lina Gao, Jacob Joseph, Yuk-Lam Ho, Wen-Chih Wu, Kelly Cho, Bryan R Gorman, Nallakkandi Rajeevan, Saiju Pyarajan, Helene Garcon, James B Meigs, Yan V Sun, Peter D Reaven, John E McGeary, Ayako Suzuki, Joel Gelernter, Julie A Lynch, Jeffrey M Petersen, Seyedeh Maryam Zekavat, Pradeep Natarajan, Sharvari Dalal, Darshana N Jhala, Mehrdad Arjomandi, Elise Gatsby, Kristine E Lynch, Robert A Bonomo, Matthew Freiberg, Gita A Pathak, Jin J Zhou, Curtis J Donskey, Ravi K Madduri, Quinn S Wells, Rose DL Huang, Renato Polimanti, Kyong-Mi Chang, Katherine P Liao, Philip S Tsao, Peter WF Wilson, Adriana M Hung, Christopher J O’Donnell, John M Gaziano, Richard L Hauger, Sudha K Iyengar, Shiuh-Wen Luoh, Million Veteran Program COVID-19 Science Initiative
发表日期
2022/11/15
期刊
American journal of respiratory and critical care medicine
卷号
206
期号
10
页码范围
1220-1229
出版商
American Thoracic Society
简介
Rationale: A common MUC5B gene polymorphism, rs35705950-T, is associated with idiopathic pulmonary fibrosis (IPF), but its role in severe acute respiratory syndrome coronavirus 2 infection and disease severity is unclear.
Objectives: To assess whether rs35705950-T confers differential risk for clinical outcomes associated with coronavirus disease (COVID-19) infection among participants in the Million Veteran Program (MVP).
Methods: The MUC5B rs35705950-T allele was directly genotyped among MVP participants; clinical events and comorbidities were extracted from the electronic health records. Associations between the incidence or severity of COVID-19 and rs35705950-T were analyzed within each ancestry group in the MVP followed by transancestry meta-analysis. Replication and joint meta-analysis were conducted using summary statistics from the COVID-19 Host Genetics Initiative (HGI). Sensitivity …
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A Verma, J Minnier, ES Wan, JE Huffman, L Gao… - American journal of respiratory and critical care …, 2022