作者
Tim B Bigdeli, Peter B Barr, Nallakkandi Rajeevan, David P Graham, Yuli Li, Jacquelyn L Meyers, Bryan R Gorman, Roseann E Peterson, Frederick Sayward, Krishnan Radhakrishnan, Sundar Natarajan, David A Nielsen, Anna V Wilkinson, Anil K Malhotra, Hongyu Zhao, Mary Brophy, Yunling Shi, Timothy J O’Leary, Theresa Gleason, Ronald Przygodzki, Saiju Pyarajan, Sumitra Muralidhar, J Michael Gaziano, Grant D Huang, John Concato, Larry J Siever, Lynn E DeLisi, Nathan A Kimbrel, Jean C Beckham, Alan C Swann, Thomas R Kosten, Ayman H Fanous, Cooperative Studies Program (CSP)# 572 O’Leary Timothy J. 16 Gleason Theresa 16 Przygodzki Ronald 16 Muralidhar Sumitra 16 Gaziano Michael 9 17 Huang Grant D. 16 Concato John 6 16 18 DeLisi Lynn E. 21, Mihaela Aslan, Philip D Harvey
发表日期
2024/3/15
期刊
Molecular psychiatry
页码范围
1-9
出版商
Nature Publishing Group UK
简介
Persons diagnosed with schizophrenia (SCZ) or bipolar I disorder (BPI) are at high risk for self-injurious behavior, suicidal ideation, and suicidal behaviors (SB). Characterizing associations between diagnosed health problems, prior pharmacological treatments, and polygenic scores (PGS) has potential to inform risk stratification. We examined self-reported SB and ideation using the Columbia Suicide Severity Rating Scale (C-SSRS) among 3,942 SCZ and 5,414 BPI patients receiving care within the Veterans Health Administration (VHA). These cross-sectional data were integrated with electronic health records (EHRs), and compared across lifetime diagnoses, treatment histories, follow-up screenings, and mortality data. PGS were constructed using available genomic data for related traits. Genome-wide association studies were performed to identify and prioritize specific loci. Only 20% of the veterans who …
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TB Bigdeli, PB Barr, N Rajeevan, DP Graham, Y Li… - Molecular psychiatry, 2024