作者
Tim B Bigdeli, Georgios Voloudakis, Peter B Barr, Bryan R Gorman, Giulio Genovese, Roseann E Peterson, David E Burstein, Vlad I Velicu, Yuli Li, Rishab Gupta, Manuel Mattheisen, Simone Tomasi, Nallakkandi Rajeevan, Frederick Sayward, Krishnan Radhakrishnan, Sundar Natarajan, Anil K Malhotra, Yunling Shi, Hongyu Zhao, Thomas R Kosten, John Concato, Timothy J O’Leary, Ronald Przygodzki, Theresa Gleason, Saiju Pyarajan, Mary Brophy, Grant D Huang, Sumitra Muralidhar, J Michael Gaziano, Mihaela Aslan, Ayman H Fanous, Philip D Harvey, Panos Roussos, M Antonelli, M de Asis, MS Bauer, F Cunningham, R Freedman, Michael Gaziano, Philip Harvey, Grant Huang, J Kelsoe, Thomas Kosten, T Lehner, JB Lohr, SR Marder, P Miller, Timothy O Leary, T Patterson, P Peduzzi, Ronald Przygodski, Larry Siever, P Sklar, S Strakowski, Ayman Fanous, W Farwell, A Malhorta, S Mane, P Palacios, Tim Bigdeli, M Corsey, L Zaluda, Juanita Johnson, Melyssa Sueiro, D Cavaliere, V Jeanpaul, Alysia Maffucci, L Mancini, J Deen, G Muldoon, Stacey Whitbourne, J Canive, L Adamson, L Calais, G Fuldauer, R Kushner, G Toney, M Lackey, A Mank, N Mahdavi, G Villarreal, EC Muly, F Amin, M Dent, J Wold, B Fischer, A Elliott, C Felix, G Gill, PE Parker, C Logan, J McAlpine, LE DeLisi, SG Reece, MB Hammer, D Agbor-Tabie, W Goodson, M Aslam, M Grainger, Neil Richtand, Alexander Rybalsky, R Al Jurdi, E Boeckman, T Natividad, D Smith, M Stewart, S Torres, Z Zhao, A Mayeda, A Green, J Hofstetter, S Ngombu, MK Scott, A Strasburger, J Sumner, G Paschall, J Mucciarelli, R Owen, S Theus, D Tompkins, SG Potkin, C Reist, M Novin, S Khalaghizadeh, Richard Douyon, Nita Kumar, Becky Martinez, SR Sponheim, TL Bender, HL Lucas, AM Lyon, MP Marggraf, LH Sorensen, CR Surerus, C Sison, J Amato, DR Johnson, N Pagan-Howard, LA Adler, S Alerpin, T Leon, KM Mattocks, N Araeva, JC Sullivan, T Suppes, K Bratcher, L Drag, EG Fischer, L Fujitani, S Gill
发表日期
2022/11/1
期刊
JAMA psychiatry
卷号
79
期号
11
页码范围
1092-1101
出版商
American Medical Association
简介
Importance
Serious mental illnesses, including schizophrenia, bipolar disorder, and depression, are heritable, highly multifactorial disorders and major causes of disability worldwide.
Objective
To benchmark the penetrance of current neuropsychiatric polygenic risk scores (PRSs) in the Veterans Health Administration health care system and to explore associations between PRS and broad categories of human disease via phenome-wide association studies.
Design, Setting, and Participants
Extensive Veterans Health Administration’s electronic health records were assessed from October 1999 to January 2021, and an embedded cohort of 9378 individuals with confirmed diagnoses of schizophrenia or bipolar 1 disorder were found. The performance of schizophrenia, bipolar disorder, and major depression PRSs were compared in participants of African or European ancestry in the Million Veteran Program …
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