作者
Haley Hunter-Zinck, Yunling Shi, Man Li, Bryan R Gorman, Sun-Gou Ji, Ning Sun, Teresa Webster, Andrew Liem, Paul Hsieh, Poornima Devineni, Purushotham Karnam, Xin Gong, Lakshmi Radhakrishnan, Jeanette Schmidt, Themistocles L Assimes, Jie Huang, Cuiping Pan, Donald Humphries, Mary Brophy, Jennifer Moser, Sumitra Muralidhar, Grant D Huang, Ronald Przygodzki, John Concato, John M Gaziano, Joel Gelernter, Christopher J O’Donnell, Elizabeth R Hauser, Hongyu Zhao, Timothy J O’Leary, Philip S Tsao, Saiju Pyarajan
发表日期
2020/4/2
期刊
The American Journal of Human Genetics
卷号
106
期号
4
页码范围
535-548
出版商
Elsevier
简介
The Million Veteran Program (MVP), initiated by the Department of Veterans Affairs (VA), aims to collect biosamples with consent from at least one million veterans. Presently, blood samples have been collected from over 800,000 enrolled participants. The size and diversity of the MVP cohort, as well as the availability of extensive VA electronic health records, make it a promising resource for precision medicine. MVP is conducting array-based genotyping to provide a genome-wide scan of the entire cohort, in parallel with whole-genome sequencing, methylation, and other ‘omics assays. Here, we present the design and performance of the MVP 1.0 custom Axiom array, which was designed and developed as a single assay to be used across the multi-ethnic MVP cohort. A unified genetic quality-control analysis was developed and conducted on an initial tranche of 485,856 individuals, leading to a high-quality …
学术搜索中的文章
H Hunter-Zinck, Y Shi, M Li, BR Gorman, SG Ji, N Sun… - The American Journal of Human Genetics, 2020