作者
Andrea Rinaldi, Michael Mian, Ekaterina Chigrinova, Luca Arcaini, Govind Bhagat, Urban Novak, Paola MV Rancoita, Cassio P De Campos, Francesco Forconi, Randy D Gascoyne, Fabio Facchetti, Maurilio Ponzoni, Silvia Govi, Andres JM Ferreri, Manuela Mollejo, Miguel A Piris, Luca Baldini, Jean Soulier, Catherine Thieblemont, Vincenzo Canzonieri, Valter Gattei, Roberto Marasca, Silvia Franceschetti, Gianluca Gaidano, Alessandra Tucci, Silvia Uccella, Maria Grazia Tibiletti, Stephan Dirnhofer, Claudio Tripodo, Claudio Doglioni, Riccardo Dalla Favera, Franco Cavalli, Emanuele Zucca, Ivo Kwee, Francesco Bertoni
发表日期
2011/2/3
期刊
Blood, The Journal of the American Society of Hematology
卷号
117
期号
5
页码范围
1595-1604
出版商
American Society of Hematology
简介
Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT …
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A Rinaldi, M Mian, E Chigrinova, L Arcaini, G Bhagat… - Blood, The Journal of the American Society of …, 2011