作者
Haiming Zhao, Yishan Chen, Lei Shao, Mingjun Xie, Jing Nie, Jingjiang Qiu, Peng Zhao, Hamed Ramezani, Jianzhong Fu, Hongwei Ouyang, Yong He
发表日期
2018/9
期刊
Small
卷号
14
期号
39
页码范围
1802630
简介
Hydrogel microspheroids are widely used in tissue engineering, such as injection therapy and 3D cell culture, and among which, heterogeneous microspheroids are drawing much attention as a promising tool to carry multiple cell types in separated phases. However, it is still a big challenge to fabricate heterogeneous microspheroids that can reconstruct built‐up tissues' microarchitecture with excellent resolution and spatial organization in limited sizes. Here, a novel airflow‐assisted 3D bioprinting method is reported, which can print versatile spiral microarchitectures inside the microspheroids, permitting one‐step bioprinting of fascinating hydrogel structures, such as the spherical helix, rose, and saddle. A microfluidic nozzle is developed to improve the capability of intricate cell encapsulation with heterotypic contact. Complex structures, such as a rose, Tai chi pattern, and single cell line can be easily printed in …
引用总数
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