查看文章

Skin wound therapy aims not only to restore skin protection but also to recover excitation functions through nerve regeneration. During the restoration of skin nerves, the recruitment of endogenous stem cells and promotion of neuronal regeneration on site work stepwise are foundations of in situ regeneration. However, current therapeutic systems usually execute each process separately, leading to limited regeneration and recovery of excitation functions. Herein, a novel self‐adaptive all‐in‐one delivery chip (G:P:Al‐Chip) is constructed that combines therapeutic protein release, gene delivery, and electrical conduction in a single microfluidic chip by 3D coaxial printing. G:P:Al‐Chip consists of an outer conductive hydrogel shell anchored with chemokine and an inner microchannel filled with enzyme‐initiated vector/plasmid DNAs microcomplexes. G:P:Al‐Chip delivers chemokine, functional plasmid DNAs, and …