作者
Michael P Diamond, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter Casson, Gregory M Christman, Joel Ager, Hao Huang, Karl R Hansen, Valerie Baker, Rebecca Usadi, Aimee Seungdamrong, G Wright Bates, R Mitchell Rosen, Daniel Haisenleder, Stephen A Krawetz, Kurt Barnhart, JC Trussell, Dana Ohl, Yufeng Jin, Nanette Santoro, Esther Eisenberg, Heping Zhang
发表日期
2015/9/24
期刊
New England Journal of Medicine
卷号
373
期号
13
页码范围
1230-1240
出版商
Massachusetts Medical Society
简介
Background
The standard therapy for women with unexplained infertility is gonadotropin or clomiphene citrate. Ovarian stimulation with letrozole has been proposed to reduce multiple gestations while maintaining live birth rates.
Methods
We enrolled couples with unexplained infertility in a multicenter, randomized trial. Ovulatory women 18 to 40 years of age with at least one patent fallopian tube were randomly assigned to ovarian stimulation (up to four cycles) with gonadotropin (301 women), clomiphene (300), or letrozole (299). The primary outcome was the rate of multiple gestations among women with clinical pregnancies.
Results
After treatment with gonadotropin, clomiphene, or letrozole, clinical pregnancies occurred in 35.5%, 28.3%, and 22.4% of cycles, and live birth in 32.2%, 23.3%, and 18.7%, respectively; pregnancy rates with letrozole were significantly lower than the rates with standard therapy …
学术搜索中的文章
MP Diamond, RS Legro, C Coutifaris, R Alvero… - New England Journal of Medicine, 2015