作者
Sorin Draghici, Purvesh Khatri, Pratik Bhavsar, Abhik Shah, Stephen A Krawetz, Michael A Tainsky
发表日期
2003/7/1
期刊
Nucleic acids research
卷号
31
期号
13
页码范围
3775-3781
出版商
Oxford University Press
简介
Onto-Tools is a set of four seamlessly integrated databases: Onto-Express, Onto-Compare, Onto-Design and Onto-Translate. Onto-Express is able to automatically translate lists of genes found to be differentially regulated in a given condition into functional profiles characterizing the impact of the condition studied upon various biological processes and pathways. OE constructs functional profiles (using Gene Ontology terms) for the following categories: biochemical function, biological process, cellular role, cellular component, molecular function and chromosome location. Statistical significance values are calculated for each category. Once the initial exploratory analysis identified a number of relevant biological processes, specific mechanisms of interactions can be hypothesized for the conditions studied. Currently, many commercial arrays are available for the investigation of specific mechanisms. Each such …
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S Draghici, P Khatri, P Bhavsar, A Shah, SA Krawetz… - Nucleic acids research, 2003