作者
Adrian E Platts, David J Dix, Hector E Chemes, Kary E Thompson, Robert Goodrich, John C Rockett, Vanesa Y Rawe, Silvina Quintana, Michael P Diamond, Lillian F Strader, Stephen A Krawetz
发表日期
2007/4/1
期刊
Human molecular genetics
卷号
16
期号
7
页码范围
763-773
出版商
Oxford University Press
简介
We are coming to appreciate that at fertilization human spermatozoa deliver the paternal genome alongside a suite of structures, proteins and RNAs. Although the role of some of the structures and proteins as requisite elements for early human development has been established, the function of the sperm-delivered RNAs remains a point for discussion. The presence of RNAs in transcriptionally quiescent spermatozoa can only be derived from transcription that precedes late spermiogenesis. A cross-platform microarray strategy was used to assess the profile of human spermatozoal transcripts from fertile males who had fathered at least one child compared to teratozoospermic individuals. Unsupervised clustering of the data followed by pathway and ontological analysis revealed the transcriptional perturbation common to the affected individuals. Transcripts encoding components of various cellular remodeling …
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