作者
Hashmat Ghanizada, Mohammad Al‐Mahdi Al‐Karagholi, Christopher S Walker, Nanna Arngrim, Tayla Rees, Jakeb Petersen, Andrew Siow, Mette Mørch‐Rasmussen, Sheryl Tan, Simon J O'Carroll, Paul Harris, Lene Theil Skovgaard, Niklas Rye Jørgensen, Margaret Brimble, Jayme S Waite, Brandon J Rea, Levi P Sowers, Andrew F Russo, Debbie L Hay, Messoud Ashina
发表日期
2021/6
期刊
Annals of neurology
卷号
89
期号
6
页码范围
1157-1171
出版商
John Wiley & Sons, Inc.
简介
Objective
Migraine is a prevalent and disabling neurological disease. Its genesis is poorly understood, and there remains unmet clinical need. We aimed to identify mechanisms and thus novel therapeutic targets for migraine using human models of migraine and translational models in animals, with emphasis on amylin, a close relative of calcitonin gene‐related peptide (CGRP).
Methods
Thirty‐six migraine without aura patients were enrolled in a randomized, double‐blind, 2‐way, crossover, positive‐controlled clinical trial study to receive infusion of an amylin analogue pramlintide or human αCGRP on 2 different experimental days. Furthermore, translational studies in cells and mouse models, and rat, mouse and human tissue samples were conducted.
Results
Thirty patients (88%) developed headache after pramlintide infusion, compared to 33 (97%) after CGRP (p = 0.375). Fourteen patients (41%) developed …
学术搜索中的文章
H Ghanizada, MAM Al‐Karagholi, CS Walker… - Annals of neurology, 2021