作者
S Bek, JV Nielsen, Anders Bo Bojesen, A Franke, Steffen Bank, U Vogel, V Andersen
发表日期
2016/9
来源
Alimentary pharmacology & therapeutics
卷号
44
期号
6
页码范围
554-567
简介
Background
Personalised medicine, including biomarkers for treatment selection, may provide new algorithms for more effective treatment of patients. Genetic variation may impact drug response and genetic markers could help selecting the best treatment strategy for the individual patient.
Aim
To identify polymorphisms and candidate genes from the literature that are associated with anti‐tumour necrosis factor (TNF) treatment response in patients with inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis.
Methods
We performed a PubMed literature search and retrieved studies reporting original data on association between polymorphisms and anti‐TNF treatment response and conducted a meta‐analysis.
Results
A functional polymorphism in FCGR3A was significantly associated with anti‐TNF treatment response among CD patients using biological response criterion (decrease in C …
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S Bek, JV Nielsen, AB Bojesen, A Franke, S Bank… - Alimentary pharmacology & therapeutics, 2016