作者
Takashi Sato, Mitsuhiro Takeno, Koichi Honma, Hideyuki Yamauchi, Yoshiaki Saito, Takao Sasaki, Hiroshi Morikubo, Yoji Nagashima, Shigeto Takagi, Kouichi Yamanaka, Takeshi Kaneko, Yoshiaki Ishigatsubo
发表日期
2006/10/15
期刊
American journal of respiratory and critical care medicine
卷号
174
期号
8
页码范围
906-914
出版商
American Thoracic Society
简介
Rationale: Heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme catabolism, has antioxidative, antiapoptotic, and antiinflammatory activities. We examined whether HO-1 might be involved in silicosis.
Objectives: To investigate whether HO-1 can reduce silicosis in mice and humans.
Methods and measurements: Silicosis was studied using a murine model, and in 46 male patients. Serum HO-1 and 8-hydroxydeoxyguanosine (a marker of oxidative stress) were measured by enzyme-linked immunosorbent assay. Levels of HO-1 were measured by immunohistochemistry and immunoblotting.
Main results: Serum HO-1 levels were significantly elevated in patients with silicosis compared with age-matched control subjects or patients with chronic obstructive pulmonary disease. Serum HO-1 levels also correlated inversely with serum 8-hydroxydeoxyguanosine levels and positively with vital capacity and forced …
引用总数
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T Sato, M Takeno, K Honma, H Yamauchi, Y Saito… - American journal of respiratory and critical care …, 2006
