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Phospholipase A₂ (PLA₂) constitutes a superfamily of enzymes that hydrolyzes the sn‐2 acyl‐chain of membrane phospholipids producing lyso‐phospholipids and free fatty acids. The products of PLA₂ have various functions, especially omega‐3 and omega‐6 fatty acids which are precursor of various eicosanoids and related metabolites involved in numerous pro‐inflammatory and pro‐resolving cellular responses. The PLA₂ superfamily is composed of six different types of enzymes, each with distinct structural features. Among them, the cytosolic PLA₂ (cPLA₂), calcium‐independent PLA₂ (iPLA₂), and secreted PLA₂ (sPLA₂) are well studied. cPLA₂ is the main provider of free arachidonic acid (AA), an omega‐6 fatty acid involved in the inflammatory cascade. Several knockout mice studies demonstrated the contribution of iPLA₂ to the metabolism of the omega‐3 fatty acid docosahexaenoic acid (DHA) in brain (J …