作者
Samantha J Broyd, Charmaine Demanuele, Stefan Debener, Suzannah K Helps, Christopher J James, Edmund JS Sonuga-Barke
发表日期
2009/3/1
来源
Neuroscience & biobehavioral reviews
卷号
33
期号
3
页码范围
279-296
出版商
Pergamon
简介
In this review we are concerned specifically with the putative role of the default-mode network (DMN) in the pathophysiology of mental disorders. First, we define the DMN concept with regard to its neuro-anatomy, its functional organisation through low frequency neuronal oscillations, its relation to other recently discovered low frequency resting state networks, and the cognitive functions it is thought to serve. Second, we introduce methodological and analytical issues and challenges. Third, we describe putative mechanisms proposed to link DMN abnormalities and mental disorders. These include interference by network activity during task performance, altered patterns of antagonism between task specific and non-specific elements, altered connectively and integrity of the DMN, and altered psychological functions served by the network DMN. Fourth, we review the empirical literature systematically. We relate DMN …
引用总数
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