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Given current evidence linking peripheral atherosclerotic disease, also known as cannabis arteritis, and acute ischemic stroke (AIS) in individuals with cannabis use disorder (CUD), we investigated the frequency and implications of CUD in relation to AIS risk and outcomes among elderly patients with peripheral vascular disease (PVD).

The National Inpatient Sample (2016–2019) was used to compare geriatric patients with PVD and cannabis use disorder CUD. CUD was correlated with AIS admissions. Adjusted multivariable regression models assessed in-hospital mortality rates.

Of 5,115,824 geriatric admissions with PVD, 50.6% were male and 77.5% were white. 21,405 admissions had cardiovascular and CUD co-occurrence. 19.7% of CUD patients had diabetes mellitus (DM), compared to 33.7% of non-CUD patients. Smoking and HTN rates were comparable between groups …