作者
Baozong Li, Bo Gao, Linbai Ye, Xue Han, Wei Wang, Lingbao Kong, Xiaonan Fang, Yingchun Zeng, Hong Zheng, Shanshan Li, Zhenghui Wu, Li Ye
发表日期
2007/3/1
期刊
Virus research
卷号
124
期号
1-2
页码范围
44-49
出版商
Elsevier
简介
Numerous viruses including hepatitis B virus (HBV) induce endoplasmic reticulum (ER) stress, which interrupts protein folding causing accumulation of unfolded or misfolded proteins in ER. To alleviate the stress placed on ER, these proteins must be refolded or degraded by activating a specific cellular response known as ER stress response or unfolded protein response (UPR). Two UPR-specific signaling pathways involving transmembrane proteins ATF6 and XBP1 generate critical transcription factors that activate UPR-responsive genes. In this study, the role of the multifunctional regulatory protein of HBV (HBx protein) in activation of UPR was investigated. In Hep3B cells with transit or stable expression of HBx, XBP1 expression and ATF6 cleavage was observed, suggesting that the ATF6 and IRE1-XBP1 pathways were activated. Furthermore, these two pathways were also activated in HepG2.2.15 cells that …
引用总数
学术搜索中的文章
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response
B Li, B Gao, L Ye, X Han, W Wang, L Kong, X Fang… - Virus research, 2007