作者
Shelagh B Coutts, Sandeep Ankolekar, Ramana Appireddy, Juan F Arenillas, Zarina Assis, Peter Bailey, Philip A Barber, Rodrigo Bazan, Brian H Buck, Ken S Butcher, Marie-Christine Camden, Bruce CV Campbell, Leanne K Casaubon, Luciana Catanese, Kausik Chatterjee, Philip MC Choi, Brian Clarke, Dar Dowlatshahi, Julia Ferrari, Thalia S Field, Aravind Ganesh, Darshan Ghia, Mayank Goyal, Stefan Greisenegger, Omid Halse, Mackenzie Horn, Gary Hunter, Oje Imoukhuede, Peter J Kelly, James Kennedy, Carol Kenney, Timothy J Kleinig, Kailash Krishnan, Fabricio Lima, Jennifer L Mandzia, Martha Marko, Sheila O Martins, George Medvedev, Bijoy K Menon, Sachin M Mishra, Carlos Molina, Aimen Moussaddy, Keith W Muir, Mark W Parsons, Andrew MW Penn, Arthur Pille, Octávio M Pontes-Neto, Christine Roffe, Joaquin Serena, Robert Simister, Nishita Singh, Neil Spratt, Daniel Strbian, Carol H Tham, M Ivan Wiggam, David J Williams, Mark R Willmot, Teddy Wu, YX Amy, George Zachariah, Atif Zafar, Charlotte Zerna, Michael D Hill, Marina Salluzzi, Nicole Blenkin, Ashley Dueck, Craig Doram, Qiao Zhang, Karla Ryckborst, Shelly Bohn, Quentin Collier, Frances Taylor, B Cord Lethebe, Anitha Jambula, Kayla Sage, Lana Toussaint, Supryia Save, Jaclyn Lee, N Laham, AA Sultan, A Deepak, A Sitaram, Andrew M Demchuk, A Lockey, A Micielli, A Wadhwa, B Arabambi, B Graham, Chrysi Bogiatzi, Darshan Doshi, D Chakraborty, Diana Kim, D Vasquez, D Singh, Dominic Tse, E Harrison, EE Smith, E Teleg, E Klourfeld, G Klein, IA Sebastian, J Evans, J Hegedus, J Kromm, K Lin, K Ignacio, Kimia Ghavami, M Ismail, M Moores, MA Panzini, M Boyko, MA Almekhlafi, Nancy Newcommon, N Maraj, O Imoukhuede, O Volny, Peter Stys, Phillipe Couillard, P Ojha, P Eswaradass, Raed Joundi, R Singh, RM Asuncion, RT Muir, S Dey, S Mansoor, S Wasyliw, S Nagendra, Sherry Hu, S Althubait, S Chen, S Bal, Stephen Van Gaal, Steven Peters, Sucharita Ray, S Chaturvedi, Suresh Subramaniam, Vivian Fu, K Villaluna, G Maclean, P King-Azote, C Ma, A Plecash, C Murphy, J Gorman, L Wilson, L Zhou, O Benevente, P Teal, S Yip
发表日期
2024/6/15
期刊
The Lancet
卷号
403
期号
10444
页码范围
2597-2605
出版商
Elsevier
简介
Background
Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality.
Methods
In this multicentre, prospective, parallel group, open label with blinded outcome assessment, randomised controlled trial, adult patients (aged ≥18 years) were included at 48 hospitals in Australia, Austria, Brazil, Canada, Finland, Ireland, New Zealand, Singapore, Spain, and the UK. Eligible patients with minor acute ischaemic stroke (National Institutes of Health Stroke Scale score 0–5) and intracranial occlusion or focal perfusion abnormality were enrolled within 12 h from stroke onset. Participants were …
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SB Coutts, S Ankolekar, R Appireddy, JF Arenillas… - The Lancet, 2024