作者
J-L Diehl, N Peron, R Chocron, B Debuc, E Guerot, C Hauw-Berlemont, B Hermann, JL Augy, R Younan, A Novara, J Langlais, L Khider, N Gendron, Guillaume Goudot, J-F Fagon, T Mirault, DM Smadja
发表日期
2020/12
期刊
Annals of intensive care
卷号
10
页码范围
1-7
出版商
Springer International Publishing
简介
Rationale
COVID-19 ARDS could differ from typical forms of the syndrome.
Objective
Pulmonary microvascular injury and thrombosis are increasingly reported as constitutive features of COVID-19 respiratory failure. Our aim was to study pulmonary mechanics and gas exchanges in COVID-2019 ARDS patients studied early after initiating protective invasive mechanical ventilation, seeking after corresponding pathophysiological and biological characteristics.
Methods
Between March 22 and March 30, 2020 respiratory mechanics, gas exchanges, circulating endothelial cells (CEC) as markers of endothelial damage, and D-dimers were studied in 22 moderate-to-severe COVID-19 ARDS patients, 1 [1–4] day after intubation (median [IQR]).
Measurements and main results
Thirteen moderate and 9 severe COVID-19 ARDS patients were studied after initiation of high PEEP protective mechanical ventilation. We …
学术搜索中的文章
JL Diehl, N Peron, R Chocron, B Debuc, E Guerot… - Annals of intensive care, 2020