作者
David M Smadja, Coralie L Guerin, Richard Chocron, Nader Yatim, Jeremy Boussier, Nicolas Gendron, Lina Khider, Jérôme Hadjadj, Guillaume Goudot, Benjamin Debuc, Philippe Juvin, Caroline Hauw-Berlemont, Jean-Loup Augy, Nicolas Peron, Emmanuel Messas, Benjamin Planquette, Olivier Sanchez, Bruno Charbit, Pascale Gaussem, Darragh Duffy, Benjamin Terrier, Tristan Mirault, Jean-Luc Diehl
发表日期
2020/11
期刊
Angiogenesis
卷号
23
页码范围
611-620
出版商
Springer Netherlands
简介
Background
Coronavirus disease-2019 (COVID-19), a respiratory disease has been associated with ischemic complications, coagulation disorders, and an endotheliitis.
Objectives
To explore endothelial damage and activation-related biomarkers in COVID-19 patients with criteria of hospitalization for referral to intensive care unit (ICU) and/or respiratory worsening.
Methods
Analysis of endothelial and angiogenic soluble markers in plasma from patients at admission.
Results
Study enrolled 40 consecutive COVID-19 patients admitted to emergency department that fulfilled criteria for hospitalization. Half of them were admitted in conventional wards without any ICU transfer during hospitalization; whereas the 20 others were directly transferred to ICU. Patients transferred in ICU were more likely to have lymphopenia, decreased SpO2 and increased D-dimer, CRP and creatinine levels. In those patients, soluble E …
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DM Smadja, CL Guerin, R Chocron, N Yatim… - Angiogenesis, 2020