作者
Timothy G Short, Douglas Campbell, Christopher Frampton, Matthew TV Chan, Paul S Myles, Tomás B Corcoran, Daniel I Sessler, Gary H Mills, Juan P Cata, Thomas Painter, Kelly Byrne, Ruquan Han, Mandy HM Chu, Davina J McAllister, Kate Leslie, M Shulman, S Wallace, C Farrington, W Gallagher, A Ditoro, P Peyton, S Baulch, A Dalyell, S Sidiropoulos, J Reynolds, J Rowley, N Tan, D McCallum, E O'Loughlin, S Wong, K Owen, IK Sim, L Glazov, P Coutts, M Pushpanathan, V Findlay, M Paech, D Cavill, A Chuan, L Pope, J Lucas, B Robinson, A Millard, S Allen, M Allen, S McKeown, P Sivalingam, T Wilkes, C Jowett, A Kearney, M Bennett, JP Favero, S Sawhney, K Drummond, S Osborn, A Wing, J Taylor, M Edwards, H Reynolds, C Town, N Terblanche, M Challis, R Seale, K Button, R Cotter, M Stewart, N Zingerle, S Hannon, D Middleton, C Edgley, S March, T McCulloch, G Wong, S Jeong, K Connell, K Kramer, G Henderson, V Ward, Y Buller, N Hird, D Scott, L Evered, G Snyder, B Silbert, P Corcoran, E Fitzgerald, S Said, A Watson, D Baby, S Bolsin, A Marriott, K Ives, BJ Wakefeld, A Jeffreys, S Bates, R Halliwell, D Elliott, L Cope, R Paranthoiene, P Peng, X Liu, X Zhou, X Jin, H Liu, L An, W Cui, L Zhang, B Jia, J Fang, E Koo, E Lo, B Fung, M Tsang, L Lam, E Pang, V Lau, G Choi, R Kwok, K Yau, B Cheng, C Lam, E Lee, D Buggy, H Keane, K Byrne, C Connolly, M Ali, A Cervantes, K Kumar, S Dandy, L Ritchie, R Kennedy, M McKellow, C Read, D France, H Truong, C Chapman, S Walker, S Olliff, H Houston, M Scott, I Minchin, A Moniwa, J McAlpine, M Chaddock, L Gray, C Czepanski, S Vinish, U Buehner, E Williams
发表日期
2019/11/23
期刊
The Lancet
卷号
394
期号
10212
页码范围
1907-1914
出版商
Elsevier
简介
Background
An association between increasing anaesthetic depth and decreased postoperative survival has been shown in observational studies; however, evidence from randomised controlled trials is lacking. Our aim was to compare all-cause 1-year mortality in older patients having major surgery and randomly assigned to light or deep general anaesthesia.
Methods
In an international trial, we recruited patients from 73 centres in seven countries who were aged 60 years and older, with significant comorbidity, having surgery with expected duration of more than 2 h, and an anticipated hospital stay of at least 2 days. We randomly assigned patients who had increased risk of complications after major surgery to receive light general anaesthesia (bispectral index [BIS] target 50) or deep general anaesthesia (BIS target 35). Anaesthetists also nominated an appropriate range for mean arterial pressure for each patient …
学术搜索中的文章
TG Short, D Campbell, C Frampton, MTV Chan… - The Lancet, 2019
