作者
Eric A Engels, Ruth M Pfeiffer, Joseph F Fraumeni, Bertram L Kasiske, Ajay K Israni, Jon J Snyder, Robert A Wolfe, Nathan P Goodrich, A Rana Bayakly, Christina A Clarke, Glenn Copeland, Jack L Finch, Mary Lou Fleissner, Marc T Goodman, Amy Kahn, Lori Koch, Charles F Lynch, Margaret M Madeleine, Karen Pawlish, Chandrika Rao, Melanie A Williams, David Castenson, Michael Curry, Ruth Parsons, Gregory Fant, Monica Lin
发表日期
2011/11/2
期刊
Jama
卷号
306
期号
17
页码范围
1891-1901
出版商
American Medical Association
简介
Context
Solid organ transplant recipients have elevated cancer risk due to immunosuppression and oncogenic viral infections. Because most prior research has concerned kidney recipients, large studies that include recipients of differing organs can inform cancer etiology.
Objective
To describe the overall pattern of cancer following solid organ transplantion.
Design, Setting, and Participants
Cohort study using linked data on solid organ transplant recipients from the US Scientific Registry of Transplant Recipients (1987-2008) and 13 state and regional cancer registries.
Main Outcome Measures
Standardized incidence ratios (SIRs) and excess absolute risks (EARs) assessing relative and absolute cancer risk in transplant recipients compared with the general population.
Results
The registry linkages yielded data on 175 732 solid organ transplants (58.4% for kidney, 21.6% for liver, 10.0% for heart, and 4.0% for lung …
引用总数
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EA Engels, RM Pfeiffer, JF Fraumeni, BL Kasiske… - Jama, 2011