作者
Noel Pabalan, Alice Salvador, Hamdi Jarjanazi, Denise Maria Christofolini, Caio Parente Barbosa, Bianca Bianco
发表日期
2014/11
期刊
Archives of gynecology and obstetrics
卷号
290
页码范围
1015-1022
出版商
Springer Berlin Heidelberg
简介
Background
Reported associations of progesterone receptor gene polymorphism (PROGINS) with endometriosis have been inconsistent.
Aim of the study
To evaluate the association between the PROGINS polymorphism and the risk of endometriosis.
Methodology
A meta-analysis of 12 published case–control studies with a total sample size of 3,321 (1,323 cases/1,998 controls) was performed. We estimated the risk (odds ratio [OR] 95 % confidence intervals) of endometriosis association with the PROGINS polymorphism.
Results
An association between the presence of the variant allele and risk of endometriosis was found, more in the homozygous and recessive models (OR 1.41–1.43, p = 0.15–0.17), and less in the dominant and co-dominant models (OR 1.22, p = 0.11–0.15 …
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N Pabalan, A Salvador, H Jarjanazi, DM Christofolini… - Archives of gynecology and obstetrics, 2014