作者
Ricard Cervera, R Serrano, GJ Pons-Estel, L Ceberio-Hualde, Yehuda Shoenfeld, E De Ramón, V Buonaiuto, Søren Jacobsen, MM Zeher, T Tarr, Angela Tincani, Marco Taglietti, G Theodossiades, E Nomikou, M Galeazzi, F Bellisai, PL Meroni, RHWM Derksen, PGD De Groot, M Baleva, Marta Mosca, Stefano Bombardieri, Frédéric Houssiau, Jean-Christophe Gris, I Quéré, Eric Hachulla, C Vasconcelos, A Fernández-Nebro, M Haro, Zahir Amoura, M Miyara, Maria Tektonidou, G Espinosa, ML Bertolaccini, MA Khamashta
发表日期
2015/6/1
期刊
Annals of the rheumatic diseases
卷号
74
期号
6
页码范围
1011-1018
出版商
BMJ Publishing Group Ltd
简介
Objectives
To assess the prevalence of the main causes of morbi-mortality in the antiphospholipid syndrome (APS) during a 10-year-follow-up period and to compare the frequency of early manifestations with those that appeared later.
Methods
In 1999, we started an observational study of 1000 APS patients from 13 European countries. All had medical histories documented when entered into the study and were followed prospectively during the ensuing 10 years.
Results
53.1% of the patients had primary APS, 36.2% had APS associated with systemic lupus erythematosus and 10.7% APS associated with other diseases. Thrombotic events appeared in 166 (16.6%) patients during the first 5-year period and in 115 (14.4%) during the second 5-year period. The most common events were strokes, transient ischaemic attacks, deep vein thromboses and pulmonary embolism. 127 (15.5%) women became pregnant (188 …
引用总数
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