作者
Geon Ha Kim, Jae Hong Lee, Sang Won Seo, Jeong Hun Kim, Joon-Kyung Seong, Byoung Seok Ye, Hanna Cho, Young Noh, Hee Jin Kim, Cindy W Yoon, Seung Jun Oh, Jae Seung Kim, Yearn Seong Choe, Kyung Han Lee, Sung Tae Kim, Jung Won Hwang, Jee Hyang Jeong, Duk L Na
发表日期
2015/1/1
期刊
Neurobiology of aging
卷号
36
期号
1
页码范围
485-491
出版商
Elsevier
简介
The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB−) positron emission tomography and to compare hippocampal volume and shape between PiB− SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB− SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB− SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB− SVaD > PiB+ AD). Both PiB− SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB− SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left …
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GH Kim, JH Lee, SW Seo, JH Kim, JK Seong, BS Ye… - Neurobiology of aging, 2015