作者
Nicholas J Shaheen, Seth D Crockett, Stephanie D Bright, Ryan D Madanick, Robert Buckmire, Marion Couch, Evan S Dellon, Joseph A Galanko, Ginny Sharpless, Douglas R Morgan, Melissa B Spacek, Paris Heidt‐Davis, David Henke
发表日期
2011/1
期刊
Alimentary pharmacology & therapeutics
卷号
33
期号
2
页码范围
225-234
出版商
Blackwell Publishing Ltd
简介
Aliment Pharmacol Ther 2011; 33: 225–234
Summary
Background Cough may be a manifestation of gastro‐oesophageal reflux disease (GERD). The utility of acid suppression in GERD‐related cough is uncertain.
Aim To assess the impact of high‐dose acid suppression with proton pump inhibitors (PPI) on chronic cough in subjects with rare or no heartburn.
Methods Subjects were nonsmokers without history of asthma, with chronic cough for >8 weeks. All subjects underwent a baseline 24‐h pH/impedance study, methacholine challenge test and laryngoscopy. Subjects were randomised to either 40 mg of esomeprazole twice daily or placebo for 12 weeks. The primary outcome measure was the Cough‐Specific Quality of Life Questionnaire (CQLQ). Secondary outcomes were response on Fisman Cough Severity/Frequency scores and change in laryngeal findings.
Results Forty subjects were …
学术搜索中的文章
NJ Shaheen, SD Crockett, SD Bright, RD Madanick… - Alimentary pharmacology & therapeutics, 2011