作者
Julie A Cornish, Emile Tan, Constantinos Simillis, Susan K Clark, Julian Teare, Paris P Tekkis
发表日期
2008/9/1
期刊
Official journal of the American College of Gastroenterology| ACG
卷号
103
期号
9
页码范围
2394-2400
出版商
LWW
简介
OBJECTIVES
Several environmental and genetic factors have been implicated to date in the development of Crohn's disease (CD) and ulcerative colitis (UC). The aim of this study was to provide a quantification of the risk of oral contraceptive pill (OCP) use in the etiology of inflammatory bowel disease.
METHODS
A literature search was performed to identify comparative studies reporting on the association of oral contraceptive use in the etiology of UC and CD between 1983 and 2007. A random-effect meta-analysis was used to compare the incidence of UC or CD between the patients exposed to the OCP and nonexposed patients. The results were adjusted for smoking.
RESULTS
A total of 75,815 patients were reported on by 14 studies, with 36,797 exposed to OCP and 39,018 nonexposed women. The pooled relative risk (RR) for CD for women currently taking the OCP was 1.51 (95% confidence interval [CI] 1.17 …
引用总数
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