作者
Jennifer S Laurent, Richard Watts, Shana Adise, Nicholas Allgaier, Bader Chaarani, Hugh Garavan, Alexandra Potter, Scott Mackey
发表日期
2020/2/1
期刊
JAMA pediatrics
卷号
174
期号
2
页码范围
170-177
出版商
American Medical Association
简介
Importance
A total of 25.7 million children in the United States are classified as overweight or obese. Obesity is associated with deficits in executive function, which may contribute to poor dietary decision-making. Less is known about the associations between being overweight or obese and brain development.
Objective
To examine whether body mass index (BMI) is associated with thickness of the cerebral cortex and whether cortical thickness mediates the association between BMI and executive function in children.
Design, Setting, and Participants
In this cross-sectional study, cortical thickness maps were derived from T1-weighted structural magnetic resonance images of a large, diverse sample of 9 and 10-year-old children from 21 US sites. List sorting, flanker, matrix reasoning, and Wisconsin card sorting tasks were used to assess executive function.
Main Outcomes and Measures
A 10-fold nested cross-validation …
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JS Laurent, R Watts, S Adise, N Allgaier, B Chaarani… - JAMA pediatrics, 2020