作者
Maxime M Bos, Neil J Goulding, M Lee, Amy Hofman, Mariska Bot, René Pool, L Vijfhuizen, Xiang Zhang, Chihua Li, Rima Mustafa, Matt J Neville, Ruifang Li-Gao, Stella Trompet, Marian Beekman, Nienke R Biermasz, Dorret I Boomsma, Irene De Boer, Constantinos Christodoulides, Abbas Dehghan, K Willems Van Dijk, Ian Ford, M Ghanbari, BT Heijmans, MA Ikram, JW Jukema, DO Mook-Kanamori, F Karpe, AI Luik, L Lumey, AM Van Den Maagdenberg, SP Mooijaart, R De Mutsert, BWJH Penninx, PCN Rensen, RC Richmond, FR Rosendaal, N Sattar, R Schoevers, PE Slagboom, GM Terwindt, CS Thesing, K Wade, CA Wijsman, G Willemsen, A Zinderman, GC Verwoert, R Noordam, DA Lawlor
发表日期
2021/8/1
期刊
Atherosclerosis
卷号
331
页码范围
e42
出版商
Elsevier
简介
Methods: The AMV analyses were conducted on data from 10 cohorts of mostly Europeans (N= 17,370). For the MR analyses (N= 38,618), we used summary results from published European-ancestry genome-wide association studies of self-reported sleep traits and of nuclear magnetic resonance (NMR) serum metabolites, and combined instruments with inverse-variance weighted (IVW) method as main analysis.
Results: We found consistent evidence from AMV and MR analyses for associations of usual vs. sometimes/rare/never insomnia symptoms with lower citrate (-0.08 standard deviation (SD)[95% confidence interval (CI):-0.12,-0.03] in AMV and-0.03 SD [-0.07,-0.003] in MR), higher glycoprotein acetyls (0.08 SD [95% CI: 0.03, 0.12] in AMV and 0.06 SD [0.03, 0.10) in MR]), lower total very large HDL particles (-0.04 SD [-0.08, 0.00] in AMV and-0.05 SD [-0.09,-0.02] in MR) and lower phospholipids in very large …
学术搜索中的文章
MM Bos, NJ Goulding, M Lee, A Hofman, M Bot, R Pool… - Atherosclerosis, 2021