作者
Elizabeth P Helzner, José A Luchsinger, Nikolaos Scarmeas, Stephanie Cosentino, Adam M Brickman, M Maria Glymour, Yaakov Stern
发表日期
2009/3/1
期刊
Archives of neurology
卷号
66
期号
3
页码范围
343-348
出版商
American Medical Association
简介
Background
Vascular factors including medical history (heart disease, stroke, diabetes, and hypertension), smoking, and prediagnosis blood lipid measurements (cholesterol: total, high-density lipoprotein, low-density lipoprotein [LDL-C], and triglyceride concentrations) may be predictors for progression of Alzheimer disease (AD).
Objective
To determine whether prediagnosis vascular risk factors are associated with progression of AD.
Design
Inception cohort followed up longitudinally for a mean of 3.5 (up to 10.2) years.
Setting
Washington Heights/Inwood Columbia Aging Project, New York, New York.
Patients
One hundred fifty-six patients with incident AD (mean age at diagnosis, 83 years).
Main Outcome Measure
Change in a composite score of cognitive ability from diagnosis onward.
Results
In generalized estimating equation models (adjusted for age, race/ethnicity, and years of education), higher cholesterol (total …
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