作者
Nikolaos Scarmeas, Lawrence S Honig, Hyunmi Choi, Julio Cantero, Jason Brandt, Deborah Blacker, Marilyn Albert, Joan C Amatniek, Karen Marder, Karen Bell, W Allen Hauser, Yaakov Stern
发表日期
2009/8/1
期刊
Archives of neurology
卷号
66
期号
8
页码范围
992-997
出版商
American Medical Association
简介
Background
Transient symptoms in Alzheimer disease (AD) are frequent and include seizures, syncope, and episodes of inattention or confusion. The incidence of seizures in AD and predictors of which patients with AD might be more predisposed to them is based primarily on retrospective studies and is not well established.
Objective
To determine the incidence and predictors of new-onset unprovoked seizures.
Design
Prospective cohort study.
Setting
Three academic centers.
Patients
Four hundred fifty-three patients with probable AD observed prospectively from mild disease stages since 1992.
Main Outcome Measure
Informant interviews every 6 months included questions about whether the patient had a seizure (convulsion, fainting, or “funny” spell) and whether diagnosis or treatment for epilepsy or seizure was made. Two epileptologists independently retrospectively reviewed all available medical records for 52 …
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N Scarmeas, LS Honig, H Choi, J Cantero, J Brandt… - Archives of neurology, 2009