作者
Federica Agosta, Pilar M Ferraro, Nilo Riva, Edoardo G Spinelli, Adriano Chio, Elisa Canu, Paola Valsasina, Christian Lunetta, Sandro Iannaccone, Massimiliano Copetti, Evelina Prudente, Giancarlo Comi, Andrea Falini, Massimo Filippi
发表日期
2016/4
期刊
Human brain mapping
卷号
37
期号
4
页码范围
1614-1626
简介
Objective
To assess the structural correlates of cognitive and behavioral impairment in motor neuron diseases (MND) using multimodal MRI.
Methods
One hundred one patients with sporadic MND (56 classic amyotrophic lateral sclerosis, 31 upper motor neuron phenotype, and 14 lower motor neuron phenotype) and 51 controls were enrolled. Patients were classified into MND with a pure motor syndrome (MND‐motor) and with cognitive/behavioral symptoms (MND‐plus). Cortical thickness measures and diffusion tensor (DT) metrics of white matter (WM) tracts were assessed. A random forest approach was used to explore the independent role of cortical and WM abnormalities in explaining major cognitive and behavioral symptoms.
Results
There were 48 MND‐motor and 53 MND‐plus patients. Relative to controls, both patient groups showed a distributed cortical thinning of the bilateral precentral gyrus …
学术搜索中的文章
F Agosta, PM Ferraro, N Riva, EG Spinelli, A Chio… - Human brain mapping, 2016