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Neuromonitoring during cardiac surgery helps prevent brain injury by detecting evidence of cerebral ischemia. Current neuromonitoring devices, such as cerebral oximeters, generally monitor one brain region, which prevents the detection of blood flow impairment in other vascular territories. A potential solution is to use a device with full-head coverage such as the newly developed high-density time-resolved NIRS system, Kernel Flow. This work aimed to assess Kernel Flow’s sensitivity to regional cerebral oxygenation changes using momentary carotid compression (CC), a paradigm that causes substantial decreases in cerebral blood flow and oxyhemoglobin (HbO) throughout the ipsilateral hemisphere. Five healthy volunteers were imaged using a Kernel Flow headset during a 30-s CC. To assess the sensitivity of the device to regional changes, the number of good quality channels was compared between four …