作者
Donald C Goff, Lisa M Sullivan, Joseph P McEvoy, Jonathan M Meyer, Henry A Nasrallah, Gail L Daumit, Steven Lamberti, Ralph B D'Agostino, Thomas S Stroup, Sonia Davis, Jeffrey A Lieberman
发表日期
2005/12/1
期刊
Schizophrenia research
卷号
80
期号
1
页码范围
45-53
出版商
Elsevier
简介
OBJECTIVE
Standardized mortality rates are elevated in schizophrenia compared to the general population. The incidence of coronary heart disease (CHD) and the relative contribution of CHD to increased mortality in schizophrenia patients are not clear, despite recent concerns about metabolic complications of certain atypical antipsychotics.
METHOD
Ten-year risk for CHD was calculated for 689 subjects who participated in the Clinical Trials of Antipsychotic Treatment Effectiveness (CATIE) Schizophrenia Trial at baseline using the Framingham CHD risk function and were compared with age-, race- and gender-matched controls from the National Health and Nutrition Examination Survey (NHANES) III.
RESULTS
Ten-year CHD risk was significantly elevated in male (9.4% vs. 7.0%) and female (6.3% vs. 4.2%) schizophrenia patients compared to controls (p=0.0001). Schizophrenia patients had significantly higher …
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DC Goff, LM Sullivan, JP McEvoy, JM Meyer… - Schizophrenia research, 2005