作者
Andriy O Samokhin, Steven Hsu, B Yu Paul, Aaron B Waxman, George A Alba, Bradley M Wertheim, C Danielle Hopkins, Frederick Bowman, Richard N Channick, Ivana Nikolic, Mariana Faria-Urbina, Paul M Hassoun, Jane A Leopold, Ryan J Tedford, Corey E Ventetuolo, Peter J Leary, Bradley A Maron
发表日期
2020/4/1
期刊
The Journal of Heart and Lung Transplantation
卷号
39
期号
4
页码范围
289-299
出版商
Elsevier
简介
BACKGROUND
Pulmonary arterial hypertension (PAH) is a highly morbid disease characterized by elevated pulmonary vascular resistance (PVR) and pathogenic right ventricular remodeling. Endothelial expression of the prometastatic protein NEDD9 is increased in fibrotic PAH arterioles, and NEDD9 inhibition decreases PVR in experimental PAH. We hypothesized that circulating NEDD9 is increased in PAH and informs the clinical profile of patients.
METHODS
Clinical data and plasma samples were analyzed retrospectively for 242 patients from 5 referral centers (2010–2017): PAH (n = 139; female 82%, 58 [48–67] years), non-PAH pulmonary hypertension (PH) (n = 54; female 56%, 63.4 ± 12.2 years), and dyspnea non-PH controls (n = 36; female 75%, 54.2 ± 14.0 years).
RESULTS
Compared with controls, NEDD9 was increased in PAH by 1.82-fold (p < 0.0001). Elevated NEDD9 correlated with PVR in …
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AO Samokhin, S Hsu, BY Paul, AB Waxman, GA Alba… - The Journal of Heart and Lung Transplantation, 2020