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Stereotactic body radiotherapy (SBRT) has been approved for the treatment of locally advanced pancreatic cancer. Placement of gold fiducials is required for real-time tracking and delivery of a high-dose therapeutic beam of radiation to the tumor. Traditionally, fiducials have been placed either intraoperatively or percutaneously. Recently, EUS-guided fiducial placement has been reported, but the safety and feasibility of this approach is not well defined.

The aim of this study was to determine the safety, feasibility, and limitations of EUS-guided placement of 0.8 × 5.0 mm fiducials via a 19-gauge needle for locally advanced and recurrent pancreatic cancer.

Prospective study of patients with either locally advanced or recurrent pancreatic cancer referred for EUS-guided fiducial placement for SBRT at our institution over a 3-year period.

Tertiary referral center conducting …