查看文章

We investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants' effects on CX3CL1/CX3CR1 interaction. We found no association of CX3CR1 with MS susceptibility. Frequency of I₂₄₉T₂₈₀ haplotype was significantly lower in SP compared to RR patients (RR>10years, OR=0.30, 95%CI=0.11–0.79, p=0.01; OR=0.53, 95%CI=0.18–1.56, p=0.2, in SP<10years vs. RR>10years). Prediction analysis showed that I249 T280 protein variant would significantly affect CX3CL1/CX3CR1 interaction. Our results suggest that CX3CR1 I₂₄₉T₂₈₀ haplotype could have protective effect for switch to SP MS. Further research is warranted to validate and replicate currently observed results.