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Methods:

A sample of 35 adults with relapsing-remitting MS completed cognitive testing and a vitamin D serum (25 [OH] D) assay. Memory assessment used clinically established neuropsychological tests with multiple testing formats to determine whether vitamin D level was associated with memory during conditions of varying retrieval demands. Intellectual functioning and mood were also assessed to control for potential confounds.

Results:

Vitamin D level was positively associated with performance on immediate and delayed recall trials of the Rey Complex Figure Test, effects that held after controlling for intelligence and disease duration. Vitamin D level was not associated with mood, intelligence, or verbal memory performance on the California Verbal Learning Test, Second Edition.

Conclusions:

Higher vitamin D level was associated with better nonverbal long-term memory performance in MS, particularly in …