作者
Pietro Maria Bertelli, Edoardo Pedrini, Jasenka Guduric-Fuchs, Elisa Peixoto, Varun Pathak, Alan W Stitt, Reinhold J Medina
发表日期
2020/3/3
来源
Current eye research
卷号
45
期号
3
页码范围
372-384
出版商
Taylor & Francis
简介
Retinal vascular diseases, such as diabetic retinopathy, retinopathy of prematurity, retinal vein occlusion, ocular ischemic syndrome and ischemic optic neuropathy, are leading causes of vision impairment and blindness. Whilst drug, laser or surgery-based treatments for the late stage complications of many of these diseases are available, interventions that target the early vasodegenerative stages are lacking. Progressive vasculopathy and ensuing ischemia is an underpinning pathology in many of these diseases, leading to hypoperfusion, hypoxia, and ultimately pathological neovascularization and/or edema in the retina and other ocular tissues, such as the optic nerve and iris. Therefore, repairing the retinal vasculature may prevent progression of ischemic retinopathies into late stage vascular complications. Various cell types have been explored for their vascular repair potential. Endothelial progenitor cells …
引用总数
2020202120222023202449832
学术搜索中的文章
PM Bertelli, E Pedrini, J Guduric-Fuchs, E Peixoto… - Current eye research, 2020