作者
Ridhima Wadhwa, Keshav Raj Paudel, Li Hian Chin, Chian Ming Hon, Thiagarajan Madheswaran, Gaurav Gupta, Jithendra Panneerselvam, Thangavelu Lakshmi, Sachin Kumar Singh, Monica Gulati, Harish Dureja, Alan Hsu, Meenu Mehta, Krishnan Anand, Hari Prasad Devkota, Jestin Chellian, Dinesh Kumar Chellappan, Philip M Hansbro, Kamal Dua
发表日期
2021/1
期刊
Journal of food biochemistry
卷号
45
期号
1
页码范围
e13572
简介
In this study, we had developed Naringenin‐loaded liquid crystalline nanoparticles (LCNs) and investigated the anti‐inflammatory and anticancer activities of Naringenin‐LCNs against human airway epithelium‐derived basal cells (BCi‐NS1.1) and human lung epithelial carcinoma (A549) cell lines, respectively. The anti‐inflammatory potential of Naringenin‐LCNs evaluated by qPCR revealed a decreased expression of IL‐6, IL‐8, IL‐1β, and TNF‐α in lipopolysaccharide‐induced BCi‐NS1.1 cells. The activity of LCNs was comparable to the positive control drug Fluticasone propionate (10 nM). The anticancer activity was studied by evaluating the antiproliferative (MTT and trypan blue assays), antimigratory (scratch wound healing assay, modified Boyden chamber assay, and immunoblot), and anticolony formation activity in A549 cells. Naringenin LCNs showed promising antiproliferative, antimigratory, and …
学术搜索中的文章
R Wadhwa, KR Paudel, LH Chin, CM Hon… - Journal of food biochemistry, 2021