作者
Waseem A Wani, Umair Baig, Sheikh Shreaz, Rayees Ahmad Shiekh, Prince Firdous Iqbal, Ehtesham Jameel, Akil Ahmad, Siti Hamidah Mohd-Setapar, Md Mushtaque, Lee Ting Hun
发表日期
2016
来源
New Journal of Chemistry
卷号
40
期号
2
页码范围
1063-1090
出版商
Royal Society of Chemistry
简介
The revelation of the anticancer properties of cisplatin has inspired research into metal complexes for the treatment of cancer. Several second and third generation cisplatin analogues were developed with claims of good anticancer properties and reduced side effects. However, the persistence of some side effects and the resistance of cancer cells have tempted scientists to explore new metal complexes as anticancer drugs. Therefore, the approach of rational drug design has been extended to the development of non-platinum anticancer drugs, and a large number of such complexes have been developed. Iron complexes are of interest to inorganic medicinal chemists for the development of anticancer agents. The anticancer potency of iron complexes was first reported in ferrocenium picrate and ferrocenium trichloroacetate salts, and was attributed to their ability to form reactive oxygen species, leading to oxidative …
引用总数
201620172018201920202021202220232024101512242326162019
学术搜索中的文章
WA Wani, U Baig, S Shreaz, RA Shiekh, PF Iqbal… - New Journal of Chemistry, 2016