作者
Lidia Anguiano, Marta Riera, Julio Pascual, José Manuel Valdivielso, Clara Barrios, Angels Betriu, Sergi Mojal, Elvira Fernández, María José Soler, investigators from the NEFRONA study, Eva Castro, Virtudes María, Teresa Molí, Meritxell Soria, Aladrén Regidor, Mª José, Almirall Jaume, Ponz Esther, Arteaga Coloma, Bajo Rubio, Belart Rodríguez, Bielsa-García Sara, Bover Sanjuan Jordi, Bronsoms Artero Josep, Cabezuelo Romero, B Juan, Muray Cases Salomé, Calviño Varela Jesús, Caro Acevedo Pilar, Carreras Bassa Jordi, Cases Amenós Aleix, Massó Jiménez Elisabet, Castilla Pérez Jesús, Cigarrán Guldris Secundino, López Prieto Saray, Comas Mongay Lourdes, Comerma Isabel, Compte Jové Mª Teresa, Cuberes Izquierdo Marta, de Álvaro Fernando, Hevia Ojanguren Covadonga, de Arriba de la Fuente Gabriel, del Pino y Pino Mª Dolores, Diaz-Tejeiro Izquierdo Rafael, Dotori Marta, Duarte Verónica, Estupiñan Torres Sara, Fernández Reyes Mª José, Fernández Rodríguez Mª Loreto, Fernández Guillermina, Galán Serrano Antonio, García Cantón Cesar, García Herrera, L Antonio, García Mena Mercedes, Gil Sacaluga Luis, Aguilar Maria, Górriz José Luis, Huarte Loza Emma, Lerma José Luis, Liebana Cañada Antonio, Marín Álvarez, Jesús Pedro, Martín Alemany Nàdia, Martín García Jesús, Martínez Castelao Alberto, Martínez Villaescusa María, Martínez Isabel, Moina Eguren Iñigo, Moreno Los Huertos Silvia, Mouzo Mirco Ricardo, Munar Vila Antonia, Muñoz Díaz Ana Beatriz, Navarro González, F Juan, Nieto Javier, Carreño Agustín, Novoa Fernández Enrique, Ortiz Alberto, Fernandez Beatriz, Paraíso Vicente, Pérez Fontán Miguel, Peris Domingo Ana, Piñera Haces Celestino, Prados Garrido Mª Dolores, Prieto Velasco Mario, Puig Marí Carmina, Rivera Gorrín Maite, Rubio Esther, Ruiz Pilar, Salgueira Lazo Mercedes, Martínez Puerto, Ana Isabel, Sánchez Tomero, José Antonio, Sánchez José Emilio, Sans Lorman Ramon, Saracho Ramon, Sarrias Maria, Prat Oreto, Sousa Fernando, Toran Daniel, Tornero Molina Fernando, Usón Carrasco, José Javier, Valera Cortes Ildefonso, Vilaprinyo del Perugia Mª Merce, Virto Ruiz, C Rafael
发表日期
2015/7/1
期刊
Nephrology Dialysis Transplantation
卷号
30
期号
7
页码范围
1176-1185
出版商
Oxford University Press
简介
Background
Patients with cardiovascular (CV) disease have an increased circulating angiotensin-converting enzyme 2 (ACE2) activity, but there is little information about changes in ACE2 in chronic kidney disease (CKD) patients without history of CV disease. We examined circulating ACE2 activity in CKD patients at stages 3–5 (CKD3-5) and in dialysis (CKD5D) without any history of CV disease.
Methods
Circulating ACE2 activity was measured in human ethylenediamine-tetraacetic acid (EDTA)-plasma samples from the NEFRONA study (n = 2572): control group (CONT) (n = 568), CKD3-5 (n = 1458) and CKD5D (n = 546). Different clinical and analytical variables such as gender; age; history of diabetes mellitus (DM), dyslipidemia and hypertension; glycaemic, renal, lipid and anaemia profiles; vitamin D analogues treatment and antihypertensive treatments (angiotensin …
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L Anguiano, M Riera, J Pascual, JM Valdivielso… - Nephrology Dialysis Transplantation, 2015