作者
A Dalmann, S Murthy, M Wannick, G Eleftheriadis, A Müller, D Zillikens, H Busch, C Sadik, G Riemekasten
发表日期
2020/6/1
来源
Annals of the Rheumatic Diseases
卷号
79
期号
Suppl 1
页码范围
1383-1383
出版商
BMJ Publishing Group Ltd
简介
Background
Regulatory IgG autoantibodies directed against diverse G protein-coupled receptors (GPCR), i.e. antibodies with agonistic or antagonistic activity are abundant in human serum. The serum titers of autoantibodies targeting angiotensin II receptor 1 (AT1) and endothelin receptor A (ETA) are specifically altered in autoimmune diseases such as systemic sclerosis (SSc). Disease-promoting mechanisms regulated by anti-AT1 and anti-ETA IgG are still elusive, but induction of pro-inflammatory and pro-fibrotic chemokines (CXCL8, CCL18) has been suggested to be one of them.
Objectives
To determine the cytokine and phospho-kinase profiles induced in monocyte-like cells by IgG derived from SSc patients (SSc-IgG) enriched with anti-AT1 and anti-ETA antibodies in comparison to IgG derived from healthy donors (IgG-HD).
Methods
A monocyte-like cell line (THP-1) was cultured in vitro and stimulated with …
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A Dalmann, S Murthy, M Wannick, G Eleftheriadis… - 2020