作者
Kerrie L Moreau, Brian L Stauffer, Wendy M Kohrt, Douglas R Seals
发表日期
2013/11/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
98
期号
11
页码范围
4507-4515
出版商
Oxford University Press
简介
Objective
In contrast to age-matched men, endurance exercise training is not consistently associated with enhanced endothelial function in estrogen-deficient postmenopausal women. We determined whether endurance exercise training improves endothelial function in postmenopausal women treated with estrogen. In a substudy, we determined if oxidative stress is mechanistically linked to endothelial function adaptations to endurance exercise training.
Participants and Design
Brachial artery flow-mediated dilation (FMD) was measured in 36 sedentary, estrogen-deficient postmenopausal women (45–65 y) at study entry (baseline), after 12 weeks of either placebo, oral (1 mg/d) estradiol, or transdermal estradiol (0.05 mg/d) (randomized), and after an additional 12 weeks of continued estradiol or placebo treatment with concurrent endurance exercise training. In subgroups of …
学术搜索中的文章
KL Moreau, BL Stauffer, WM Kohrt, DR Seals - The Journal of Clinical Endocrinology & Metabolism, 2013