作者
Terri R Fried, John O'Leary, Virginia Towle, Mary K Goldstein, Mark Trentalange, Deanna K Martin
发表日期
2014/12
来源
Journal of the American Geriatrics Society
卷号
62
期号
12
页码范围
2261-2272
简介
Objectives
To summarize evidence regarding the health outcomes associated with polypharmacy, defined as number of prescribed medications, in older community‐dwelling persons.
Design
Systematic review of MEDLINE (OvidSP 1946 to May, Week 3, 2014).
Setting
Community.
Participants
Observational studies examining health outcomes according to number of prescription medications taken.
Measurements
Association between number of medications and health outcomes. Because of the importance of comorbidity as a potential confounder of the relationship between polypharmacy and health outcomes, articles were assessed regarding the quality of their adjustment for confounding.
Results
Of the 50 studies identified, the majority that were rated good in terms of their adjustment for comorbidity demonstrated relationships between polypharmacy and a range of outcomes, including falls, fall outcomes …
学术搜索中的文章
Health outcomes associated with polypharmacy in community‐dwelling older adults: a systematic review
TR Fried, J O'Leary, V Towle, MK Goldstein… - Journal of the American Geriatrics Society, 2014