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The cannabinoids comprise three major classes of substances, including compounds derived from the cannabis plant (e.g. Δ⁹‐tetrahydrocannabinol and the chemically related substances CP55940 and HU210), endogenously formed (e.g. anandamide) and synthetic compounds (e.g. WIN55212‐2). Beyond their psychotropic effects, cannabinoids have complex effects on blood pressure, including biphasic changes of Δ⁹‐tetrahydrocannabinol and WIN55212‐2 and an even triphasic effect of anandamide. The differing pattern of blood pressure changes displayed by the three types of compounds is not really surprising since, although they share an agonistic effect at cannabinoid CB₁ and CB₂ receptors, some compounds have additional effects. In particular, anandamide is known for its pleiotropic effects, and there is overwhelming evidence that anandamide influences blood pressure via (i) CB₁ receptors, (ii …