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Considering the psychological problems of people with physical disabilities, especially in adolescence, and the importance of paying attention to them to improve their mental health, the present study aimed at investigating the effectiveness of short-term solution-focused approach training on vitality and resilience of students with physical disabilities. It was a quasi-experimental study with pretest, posttest and the control group. From among all high school students with physical disabilities in the city of Isfahan, 30 students were selected through convenience sampling method and were randomly divided into experimental and control groups. Deci Vitality Questionnaire and Conner and Davidson Resilience Scale were applied to both groups, and the experimental group received ten 45-minute sessions of solution-focused intervention once a week. Data were analyzed using multivariate analysis of covariance. The results showed that group training of solution-focused therapy had a significant influence on vitality and the negative affect tolerance of students with physical disabilities, but was not significant on overall resilience. It seems that solution-focused approach can be utilized to promote the positive psychological indicators such as vitality and negative affect tolerance in people with physical disabilities.