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Fabricating new biosensing constructs with high selectivity and sensitivity is the most needed environmental detection tool. In this context, several nanostructured materials have been envisaged to construct biosensors to achieve superior selectivity and sensitivity. Among them, MXene is regarded as the most promising to develop biosensors due to its fascinating attributes, like high surface area, excellent thermal resistance, good hydrophilicity, unique layered topology, high electrical conductivity, and environmentally–friendlier properties. MXenes-based materials have emerged as a prospective for catalysis, energy storage, electronics, and environmental sensing and remediation applications thanks to the above-mentioned exceptional characteristics. This review elaborates on the contemporary and state-of-the-art advancements in MXene-based electrochemical and biosensing tools to detect toxic elements …