作者
Jennifer Ken-Opurum, Sesha SS Srinivas, Pratyusha Vadagam, Lang Faith, Seojin Park, Scott Charland, Andrew Revel, Ronald Preblick
发表日期
2023/4
期刊
Journal of Comparative Effectiveness Research
卷号
12
期号
4
页码范围
e220196
出版商
Becaris Publishing Ltd
简介
Aim
The budgetary consequences of increasing dronedarone utilization for treatment of atrial fibrillation were evaluated from a US payer perspective.
Materials & methods
A budget impact model over a 5-year time horizon was developed, including drug-related costs and risks for long-term clinical outcomes (LTCOs). Treatments included antiarrhythmic drugs (AADs; dronedarone, amiodarone, sotalol, propafenone, dofetilide, flecainide), rate control medications, and ablation. Direct comparisons and temporal and non-temporal combination scenarios investigating treatment order were analyzed as costs per patient per month (PPPM).
Results
By projected year 5, costs PPPM for dronedarone versus other AADs decreased by 37.69duetofewerLTCOs,treatmentwithdronedaroneversusablationorratecontrolmedications+ablationresultedincostsavings( 359.94 and 370.54,respectively …
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J Ken-Opurum, SSS Srinivas, P Vadagam, L Faith… - Journal of Comparative Effectiveness Research, 2023