作者
Shravya Rao Madku, Bijaya Ketan Sahoo, K Lavanya, Ragaiahgari Srinivas Reddy, Anna Tanuja Safala Bodapati
发表日期
2023/1/15
期刊
International Journal of Biological Macromolecules
卷号
225
页码范围
745-756
出版商
Elsevier
简介
The binding studies of DNA with small molecules have been an emerging field of research all the time since DNA as the genetic material is a major biological target for various drugs. Interpretation of small molecule-DNA binding helps in understanding their interactions with designing new drugs of greater medicinal activity. Posaconazole is an antifungal drug in the class of triazoles which are known to possess numerous pharmacological properties. In this work, the nature of the binding of posaconazole with calf-thymus DNA has been studied using spectroscopic techniques and molecular docking studies. A binding constant of the order of 103 M−1 was observed from UV–visible and fluorescence studies for the interaction between posaconazole and calf-thymus DNA. The fluorescence property of posaconazole was found to be quenched by calf-thymus DNA with a quenching constant of the order of 103 M−1 …
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SR Madku, BK Sahoo, K Lavanya, RS Reddy… - International Journal of Biological Macromolecules, 2023